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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1995-5-2
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pubmed:abstractText |
We purified and characterized an unusual antimicrobial peptide, prophenin-1 (PF-1), from porcine leukocytes. The peptide had a mass of 8,683 and contained 79 residues, including 42 (53.2%) prolines and 15 (19.0%) phenylalanines. Its N-terminal 60 residues consisted of three perfect and three nearly perfect repeats of a decamer, FPPPNFPGPR. Prophenin-1 was encoded on a cathelin-containing precursor and showed substantially more activity against E. coli, a Gram-negative bacterium, than against Listeria monocytogenes, a Gram-positive organism, in vitro.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0014-5793
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
362
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
65-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7698355-Amino Acid Sequence,
pubmed-meshheading:7698355-Animals,
pubmed-meshheading:7698355-Anti-Bacterial Agents,
pubmed-meshheading:7698355-Escherichia coli,
pubmed-meshheading:7698355-Leukocytes,
pubmed-meshheading:7698355-Listeria monocytogenes,
pubmed-meshheading:7698355-Microbial Sensitivity Tests,
pubmed-meshheading:7698355-Molecular Sequence Data,
pubmed-meshheading:7698355-Molecular Weight,
pubmed-meshheading:7698355-Proteins,
pubmed-meshheading:7698355-Swine
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pubmed:year |
1995
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pubmed:articleTitle |
Prophenin-1, an exceptionally proline-rich antimicrobial peptide from porcine leukocytes.
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pubmed:affiliation |
Department of Medicine, UCLA School of Medicine 90095, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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