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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1995-5-4
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pubmed:abstractText |
Regulated secretion by mast cells is known to be controlled by GTP-binding proteins, but the proteins involved have not been identified. Rac and Rho, two small GTPases related to the oncoprotein Ras, mediate transmission of signals from cell-surface receptors to the actin cytoskeleton. In rat mast cells, both Rac and Rho participate in effecting the centripetal redistribution of filamentous actin that is observed after stimulation of the cells. Rho is responsible for polymerization of actin filaments in the cell interior, whereas Rac is required for the entrapment in the interior of filaments released from the cortex. Such cytoskeletal changes could be important in control of the exocytotic process, so we examined whether Rac and Rho also play a role in regulated secretion by mast cells.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/GTP Phosphohydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/rac GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/rhoA GTP-Binding Protein
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0960-9822
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
5
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pubmed:geneSymbol |
Rac1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
68-73
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7697350-Animals,
pubmed-meshheading:7697350-Calcium,
pubmed-meshheading:7697350-Cell Degranulation,
pubmed-meshheading:7697350-Exocytosis,
pubmed-meshheading:7697350-GTP Phosphohydrolases,
pubmed-meshheading:7697350-GTP-Binding Proteins,
pubmed-meshheading:7697350-Mast Cells,
pubmed-meshheading:7697350-Rats,
pubmed-meshheading:7697350-rac GTP-Binding Proteins,
pubmed-meshheading:7697350-rhoA GTP-Binding Protein
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pubmed:year |
1995
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pubmed:articleTitle |
The small GTPases Rac and Rho as regulators of secretion in mast cells.
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pubmed:affiliation |
Physiology Department, University College London, UK.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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