Linked Life Data

7696618

Source:http://linkedlifedata.com/resource/pubmed/id/7696618

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
1995-5-4
pubmed:abstractText
RNA editing has been shown to be critical in generating the molecular diversity of rodent kainate receptors. We have examined cDNAs derived from various human brain sources to assess the occurrence and extent of RNA editing in human brain. Comparison of genomic and cDNA sequences revealed extensive editing of the human EAA4 (GluR6) mRNA at the isoleucine/valine, tyrosine/cysteine sites of the transmembrane I region, and the glutamine/arginine site of the transmembrane II region. Of the eight potential molecular variants generated by the nucleotide exchange, five were observed in the tissues examined. The distribution of the various RNA editing combinations were not uniform, and displayed tissue and/or age dependent distribution. Editing of the glutamine/arginine site was also confirmed for EAA3 (GluR5), which displays a significantly higher extent of editing in specific human brain regions compared with rodent whole brain. Hence, it can be concluded that RNA editing is a determinant of the phenotype of human kainate receptor complexes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2625-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
RNA editing of human kainate receptor subunits.
pubmed:affiliation
Allelix Biopharmaceuticals Inc., Mississauga, Ontario, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't