Linked Life Data

7695790

Source:http://linkedlifedata.com/resource/pubmed/id/7695790

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1995-5-3
pubmed:abstractText
Steatosis is the most common although inconstant hepatic lesion induced by chronic alcohol consumption. Alcoholic cirrhosis is found in only 20 to 30% of chronic alcohol misusers, which points to the influence of both environmental and genetic factors. Apolipoprotein E (apo E) presents an important polymorphism with three common alleles, epsilon 4, epsilon 3 and epsilon 2. Its modulation role on triglyceride-rich lipoproteins and cholesterol-containing lipoproteins is linked with its interaction with cellular specific receptors. This work aims at studying a possible correlation between apo E polymorphism and alcoholic cirrhosis. The three common alleles were identified by enzymatic amplification (PCR) of genomic DNA from blood samples and analysis of restriction profiles. The distribution of alleles and genotypes was performed in 35 Caucasian cirrhotic patients (medium age 57 years) and compared with the usual distribution of apo E phenotypes in European Caucasian populations. The results show lower epsilon 4 and epsilon 2 allele frequencies and higher epsilon 3 allele frequency in Caucasian alcoholic cirrhotics.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0735-0414
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
715-8
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Genetic polymorphism of apolipoprotein E in Caucasian alcoholic cirrhotics.
pubmed:affiliation
Département de Biochimie Médicale et Biologie Moléculaire, Université de Bordeaux, France.
pubmed:publicationType
Journal Article