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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1995-4-24
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pubmed:databankReference |
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pubmed:abstractText |
Sry is the testes determining factor gene located on the Y chromosome. We sought sequence variation in potential promoter regions that might explain the gradiation in sex reversal seen when different domesticus strains are bred to C57BL/6J females since sequence variation previously found in the coding region is not sufficient to explain it. Dideoxy sequencing identified a 10 bp deletion in the 5' flanking region limited to YDOM chromosomes of weak effect. A PCR strategy to search for deletions in this region disclosed another deletion which was shown to be different by sequencing.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
208
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
624-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:7695616-Animals,
pubmed-meshheading:7695616-Base Sequence,
pubmed-meshheading:7695616-DNA Primers,
pubmed-meshheading:7695616-DNA-Binding Proteins,
pubmed-meshheading:7695616-Female,
pubmed-meshheading:7695616-Gene Expression Regulation, Developmental,
pubmed-meshheading:7695616-Male,
pubmed-meshheading:7695616-Mice,
pubmed-meshheading:7695616-Mice, Inbred C57BL,
pubmed-meshheading:7695616-Molecular Sequence Data,
pubmed-meshheading:7695616-Nuclear Proteins,
pubmed-meshheading:7695616-Promoter Regions, Genetic,
pubmed-meshheading:7695616-RNA, Messenger,
pubmed-meshheading:7695616-Sequence Deletion,
pubmed-meshheading:7695616-Sex Determination Analysis,
pubmed-meshheading:7695616-Sex-Determining Region Y Protein,
pubmed-meshheading:7695616-Transcription Factors
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pubmed:year |
1995
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pubmed:articleTitle |
Sequence variation in the 5', putative promoter of Sry and its possible relevance to the C57BL/6J-YDOM sex reversal.
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pubmed:affiliation |
Department of Pediatrics, University of Arizona, Tucson 85724.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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