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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1993-12-23
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pubmed:abstractText |
1. Diabetes had no significant effect on IGFBP-3 message and serum levels however, subsequent insulin treatment caused more than a two-fold increase in both hepatic IGFBP-3 mRNA and serum levels above controls (P < 0.05). 2. The induction of diabetes in pigs significantly increased the steady state levels of IGFBP-2 mRNA in the liver of young swine (P < 0.05). 3. Both liver message and serum IGFBP-2 were reduced to control levels with insulin therapy. 4. We report here that in addition to its affects on IGFBP-2, insulin is involved in the regulation of IGFBP-3 expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0305-0491
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
341-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:7694822-Animals,
pubmed-meshheading:7694822-Carrier Proteins,
pubmed-meshheading:7694822-Diabetes Mellitus, Experimental,
pubmed-meshheading:7694822-Growth Inhibitors,
pubmed-meshheading:7694822-Insulin,
pubmed-meshheading:7694822-Insulin-Like Growth Factor Binding Protein 2,
pubmed-meshheading:7694822-Insulin-Like Growth Factor Binding Proteins,
pubmed-meshheading:7694822-Liver,
pubmed-meshheading:7694822-Male,
pubmed-meshheading:7694822-RNA, Messenger,
pubmed-meshheading:7694822-Swine
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pubmed:year |
1993
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pubmed:articleTitle |
Insulin-like growth-factor binding protein (IGFBP) serum levels and hepatic IGFBP-2 and -3 mRNA expression in diabetic and insulin-treated swine (Sus scrofa).
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pubmed:affiliation |
Department of Animal Science, University of Minnesota, St Paul 55108.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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