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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-1-6
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pubmed:abstractText |
We investigated the effects of anti-murine CD44 monoclonal antibodies on the activation of antigen-specific T cell hybridomas. Anti-murine CD44 antibodies by themselves did not induce the production of IL-2 by antigen-specific T cell hybridomas. However, anti-murine CD44 monoclonal antibodies were able to either inhibit or enhance the production of IL-2, depending on the other monoclonal antibodies used as comitogenic stimuli. When a T cell hybridoma was activated by antigen and antigen-presenting cells or anti-CD3 antibodies, addition of anti-CD44 antibodies inhibited IL-2 production. In contrast, monoclonal anti-CD44 antibodies acted in synergy with anti-human CD2 antibodies in stimulating a murine T cell hybridoma stably transfected with the human CD2 gene to produce IL-2. Therefore, cross-linking of surface CD44 is able to deliver either a positive or a negative signal in murine antigen-specific T cell hybridomas. One of the ligands for CD44 is hyaluronic acid. Hyaluronic acid in vitro significantly increased the activation of murine T cell hybridomas. Hyaluronic acid itself was mitogenic for T cell hybridomas. Therefore, in addition to being an adhesion molecule, CD44 functions as a signal-transducing molecule on murine T cell hybridomas.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD2,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD44,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Hyaluronic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogens,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Lymphocyte Homing
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0008-8749
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
152
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
186-99
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7694807-Animals,
pubmed-meshheading:7694807-Antibodies, Monoclonal,
pubmed-meshheading:7694807-Antigen-Presenting Cells,
pubmed-meshheading:7694807-Antigens, CD2,
pubmed-meshheading:7694807-Antigens, CD3,
pubmed-meshheading:7694807-Antigens, CD44,
pubmed-meshheading:7694807-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:7694807-Drug Synergism,
pubmed-meshheading:7694807-Humans,
pubmed-meshheading:7694807-Hyaluronic Acid,
pubmed-meshheading:7694807-Hybridomas,
pubmed-meshheading:7694807-Interleukin-2,
pubmed-meshheading:7694807-Male,
pubmed-meshheading:7694807-Mice,
pubmed-meshheading:7694807-Mice, Inbred BALB C,
pubmed-meshheading:7694807-Mitogens,
pubmed-meshheading:7694807-Receptors, Antigen, T-Cell,
pubmed-meshheading:7694807-Receptors, Immunologic,
pubmed-meshheading:7694807-Receptors, Lymphocyte Homing,
pubmed-meshheading:7694807-Signal Transduction,
pubmed-meshheading:7694807-Transfection
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pubmed:year |
1993
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pubmed:articleTitle |
Monoclonal anti-CD44 antibody acts in synergy with anti-CD2 but inhibits anti-CD3 or T cell receptor-mediated signaling in murine T cell hybridomas.
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pubmed:affiliation |
Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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