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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1993-12-9
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|
pubmed:abstractText |
PDGF promotes growth of smooth muscle cells (SMCs) and induces morphological changes. We investigated the effects of PDGF on cell-matrix adhesion of SMCs. PDGF reorganized integrin distribution as well as actin filament structure. PDGF-treated cells attached more loosely to fibronectin than non-treated cells. Decreased expression of alpha-actin by PDGF was antagonized by coating culture dishes with fibronectin but not with vitronectin and laminin. The inhibition of cell adhesion by GRGDSP oligopeptide and anti-fibronectin receptor antibody led to the reduction in alpha-actin expression. These results suggest that PDGF may modulate phenotype of SMCs by altering fibronectin-integrin interaction.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-291X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
196
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
997-1002
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7694583-Actins,
pubmed-meshheading:7694583-Animals,
pubmed-meshheading:7694583-Cell Adhesion,
pubmed-meshheading:7694583-Cell Line,
pubmed-meshheading:7694583-Dose-Response Relationship, Drug,
pubmed-meshheading:7694583-Extracellular Matrix,
pubmed-meshheading:7694583-Fibronectins,
pubmed-meshheading:7694583-Glycoproteins,
pubmed-meshheading:7694583-Humans,
pubmed-meshheading:7694583-Kinetics,
pubmed-meshheading:7694583-Laminin,
pubmed-meshheading:7694583-Muscle, Smooth, Vascular,
pubmed-meshheading:7694583-Oligopeptides,
pubmed-meshheading:7694583-Phenotype,
pubmed-meshheading:7694583-Platelet-Derived Growth Factor,
pubmed-meshheading:7694583-Pulmonary Artery,
pubmed-meshheading:7694583-Rats,
pubmed-meshheading:7694583-Recombinant Proteins,
pubmed-meshheading:7694583-Vitronectin
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pubmed:year |
1993
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pubmed:articleTitle |
Altered fibronectin-dependent cell adhesion by PDGF accompanies phenotypic modulation of vascular smooth muscle cells.
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pubmed:affiliation |
Center for Adult Diseases, Osaka, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
