|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003250,
umls-concept:C0018270,
umls-concept:C0032150,
umls-concept:C0169904,
umls-concept:C1269955,
umls-concept:C1514562,
umls-concept:C1533691,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221,
umls-concept:C2699153
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1993-11-26
|
|
pubmed:abstractText |
A major protein found on the surface of the invasive stage of the malaria parasite Plasmodium falciparum, merozoite surface protein-1 (MSP1), has been proposed as a vaccine candidate. Antibodies which recognise a single fragment of this molecule (MSP1(19)), composed of 2 regions related to epidermal growth factor (EGF), also inhibit parasite growth in vitro. It is shown by direct expression of the individual EGF-like domains in Escherichia coli, that the first domain is the target of growth-inhibitory antibodies. A single amino acid difference influences the binding of some antibodies to this domain.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Protozoan,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Protozoan,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Protozoan,
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Malaria Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Merozoite Surface Protein 1,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/Protozoan Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0166-6851
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
60
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
303-11
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:7694147-Amino Acid Sequence,
pubmed-meshheading:7694147-Animals,
pubmed-meshheading:7694147-Antibodies, Monoclonal,
pubmed-meshheading:7694147-Antibodies, Protozoan,
pubmed-meshheading:7694147-Antigens, Protozoan,
pubmed-meshheading:7694147-Antigens, Surface,
pubmed-meshheading:7694147-Base Sequence,
pubmed-meshheading:7694147-DNA, Protozoan,
pubmed-meshheading:7694147-Epidermal Growth Factor,
pubmed-meshheading:7694147-Epitopes,
pubmed-meshheading:7694147-Escherichia coli,
pubmed-meshheading:7694147-Gene Expression,
pubmed-meshheading:7694147-Malaria, Falciparum,
pubmed-meshheading:7694147-Malaria Vaccines,
pubmed-meshheading:7694147-Merozoite Surface Protein 1,
pubmed-meshheading:7694147-Molecular Sequence Data,
pubmed-meshheading:7694147-Plasmodium falciparum,
pubmed-meshheading:7694147-Protein Precursors,
pubmed-meshheading:7694147-Protozoan Proteins,
pubmed-meshheading:7694147-Recombinant Fusion Proteins
|
|
pubmed:year |
1993
|
|
pubmed:articleTitle |
Monoclonal antibodies that inhibit Plasmodium falciparum invasion in vitro recognise the first growth factor-like domain of merozoite surface protein-1.
|
|
pubmed:affiliation |
Division of Parasitology, National Institute for Medical Research, Mill Hill, London, UK.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
