Linked Life Data

7693915

Source:http://linkedlifedata.com/resource/pubmed/id/7693915

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-11-29
pubmed:abstractText
The effect of morphine treatment on immunocompetence was investigated in rhesus monkeys (Mucaca mulatta). Monkeys that received morphine daily (3.2 mg/kg) had suppressed peripheral blood mononuclear cell (PBMC) natural killer (NK) activity as well as a decrease in the percentage of CD8+CD16+ cells compared with saline-treated (controls) or infrequently treated (i.e., opioids once or twice weekly) monkeys. However, an increase (20 +/- 5%) in the percentage of CD8+ lymphocytes was found in both the daily and infrequent opioid-treated monkeys compared with controls. Conversely, the percentage of total CD4+ lymphocytes and CD4+CD45RA+ was reduced (12 +/- 2% and 28 +/- 10% respectively) in both daily and infrequent opioid-treated animals compared with saline-treated controls. In a reciprocal fashion, there was an increase in the CD4+CD29+ population in daily morphine-treated monkeys (54% of the total CD4+ cells) compared with untreated animals (37% of the total CD4+ cells). In addition, cultured PBMC obtained from monkeys treated daily with morphine produced significantly (P < .01) more polyclonal immunoglobulin (Ig) G (366 ng/ml) and polyclonal IgM (233 ng/ml) compared with PBMC production of polyclonal IgG (96 ng/ml) and polyclonal IgM (67 ng/ml) from saline-treated controls. However, no differences were found in the percentage of CD19+ lymphocytes among any of the groups. In summary, daily treatment with a relatively low dose of morphine (3.2 mg/kg) affects immunocompetence which could have important implications in the regulation of viral pathogens in i.v. drug abusers (e.g., AIDS).
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
267
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9-15
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Immune alterations in morphine-treated rhesus monkeys.
pubmed:affiliation
Department of Microbiology, Immunology and Parasitology, Louisiana State University Medical Center, New Orleans.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't