Linked Life Data

7692690

Source:http://linkedlifedata.com/resource/pubmed/id/7692690

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-11-22
pubmed:abstractText
Several studies suggest that galanin stimulates growth hormone release through effects on the hypothalamus. It is not known if galanin has acute effects directly on the somatotrophs. We now find that 0.5 mumol/l galanin stimulates growth hormone release within the first minute of exposure in isolated, purified, cultured male rat somatotrophs. The effect persisted for 15 min and was reversible when galanin was omitted. Galanin reduced the effect of 1 nmol/l growth hormone-releasing hormone (hGHRH(1-29)) on growth hormone release. Galanin stimulated 45Ca efflux from prelabelled cells but had no effect on 86Rb efflux (tracer for potassium). The findings support the fact that galanin can stimulate growth hormone release directly at the level of the somatotrophs. The cellular mechanisms for the effect of galanin probably differ from those of growth hormone-releasing hormone.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0001-5598
pubmed:author
pubmed:issnType
Print
pubmed:volume
129
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
268-72
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Effects of galanin on growth hormone release in isolated cultured rat somatotrophs.
pubmed:affiliation
Department of Histology and Cell Biology, University of Umeå, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't