Linked Life Data

7692156

Source:http://linkedlifedata.com/resource/pubmed/id/7692156

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-11-16
pubmed:abstractText
The relation between norepinephrine (NE)-induced contraction and inositol phosphate (IP) formation was investigated in aorta and tail artery rings from adult spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY). Norepinephrine (NE) contracted the tail artery of WKY and SHR with similar potency (-log EC50 6.6 +/- 0.1 and 6.5 +/- 0.08, respectively), but the maximum tension developed by SHR (0.98 +/- 0.03 g weight) was greater as compared with WKY (0.75 +/- 0.09 g weight). [3H]IP accumulation in the NE-stimulated tail artery was enhanced (p < 0.05-0.01) in SHR as compared with WKY, the potency exhibited being similar in both groups of rats. In aortic rings, in contrast, sensitivity to NE was reduced in SHR as compared with WKY rats (-log EC50 7.92 +/- 0.16 and 8.44 +/- 0.14, respectively) whereas the maximum developed tension was similar. There was also a nonsignificant trend for [3H]IP formation to be impaired in SHR as compared with WKY. Furthermore, results obtained in Ca(2+)-free medium appears to indicate that the contribution of intracellular calcium to NE-induced contraction is greater in tail artery than in aorta. Together, these data suggest that differences in alpha 1-adrenoceptor-mediated contraction observed between blood vessels of SHR and WKY are associated with qualitatively similar alterations in the [3H]IP accumulation linked to alpha 1-adrenoceptor stimulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0160-2446
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
191-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Inositol phosphate formation and contractile response linked to alpha 1-adrenoceptor in tail artery and aorta from spontaneously hypertensive and Wistar-Kyoto rats.
pubmed:affiliation
Departament de Farmacologia i Psiquiatria, Universitat Autònoma de Barcelona, Bellaterra, Spain.
pubmed:publicationType
Journal Article, In Vitro