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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1993-11-24
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pubmed:abstractText |
Vaccination against human immunodeficiency virus type 1 (HIV-1) requires an immunogen which will elicit a protective immunity against viruses that show a high degree of genetic polymorphism. Therefore, the identification of neutralizing epitopes which are shared by many strains would be useful. In previous studies, we established a human monoclonal antibody (2F5) that neutralizes a variety of laboratory strains and clinical isolates of HIV-1. In the present report, we define the amino acid sequence Glu-Leu-Asp-Lys-Trp-Ala (ELDKWA) on the ectodomain of gp41 as the epitope recognized by this antibody. The sequence was found to be conserved in 72% of otherwise highly variable HIV-1 isolates. Escape mutants were not detected in cells infected with HIV-1 isolates MN and RF in the presence of antibody 2F5. Since sequence variability of neutralizing epitopes is considered to be a major obstacle to HIV-1 vaccine development, the conserved B-cell epitope described here is a promising candidate for inclusion in a vaccine against AIDS.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-1370580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-1383131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-1690424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-1696028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-1700002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-1703322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-1909456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-2006168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-2072448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-2326277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-2328092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-2370681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-2392685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-2450351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-2460925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-2483618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-2542797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-2838179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-2915387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-2992084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-3162762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-3261775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-3388046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-3466790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-3639669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-3639908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-388439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-7682083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7692082-8474172
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6642-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7692082-Amino Acid Sequence,
pubmed-meshheading:7692082-Antibodies, Monoclonal,
pubmed-meshheading:7692082-Base Sequence,
pubmed-meshheading:7692082-Epitopes,
pubmed-meshheading:7692082-HIV Antibodies,
pubmed-meshheading:7692082-HIV Antigens,
pubmed-meshheading:7692082-HIV Envelope Protein gp41,
pubmed-meshheading:7692082-HIV-1,
pubmed-meshheading:7692082-Molecular Sequence Data,
pubmed-meshheading:7692082-Neutralization Tests
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pubmed:year |
1993
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pubmed:articleTitle |
A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1.
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pubmed:affiliation |
Institut für Angewandte Mikrobiologie, Universität für Bodenkultur, Wien, Austria.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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