Linked Life Data

7691245

Source:http://linkedlifedata.com/resource/pubmed/id/7691245

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1993-11-10
pubmed:abstractText
Inflammatory malignant fibrous histiocytomas (IMFH) are rare tumors and are frequently associated with leukocytosis. In rare cases, leukemoid reactions were attributed to tumor production of unidentified hematopoietic factors. In this study, we used immunohistochemical techniques to show cytokine immunoreactivity in the malignant cells of two cases of IMFH presenting with leukemoid reactions and compared them with two malignant fibrous histocytomas, noninflammatory type. All four tumors stained positively for stem cell factor (SCF), granulocyte colony-stimulating factor (G-CSF), interleukin-2 (IL-2), IL-4, IL-5, interferon-alpha (IFN-alpha), and insulin-like growth factor-I. Other cytokines detected only in the two IMFH included IL-6, IL-7, IL-8, IFN-gamma, and keratinocyte growth factor. Granulocyte-macrophage-CSF, IL-3, and transforming growth factor-beta staining was present in one of the two IMFH tumors and was not present in the noninflammatory tumors. The immunohistochemical staining was localized to the malignant cells, suggesting deregulated cytokine expression consistent with their monocytic/histocytic origin. Expression of certain cytokines in the IMFH may account for the local inflammatory infiltrate, tumor fibrosis, and the aggressive nature of the malignant cells. We also detected elevated serum levels of SCF, G-CSF, IL-6, and tumor necrosis factor in one or both of the IMFH patients. These latter observations may explain the bone marrow hypercellularity and other paraneoplastic symptoms, including fever, malaise, and weight loss, observed in both patients. Different cytokines present in the two IMFH tumors appear to be responsible for the eosinophilic leukemoid reaction observed in one case and for the granulocytic leukemoid reaction observed in the other patient. They may also be responsible for expansion of the tumor-cell population, fibroblast proliferation, and enhanced secretion of extracellular collagen.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0006-4971
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
82
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2038-44
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:7691245-Aged, pubmed-meshheading:7691245-Bone Marrow, pubmed-meshheading:7691245-Cytokines, pubmed-meshheading:7691245-Granulocyte Colony-Stimulating Factor, pubmed-meshheading:7691245-Growth Substances, pubmed-meshheading:7691245-Hematopoietic Cell Growth Factors, pubmed-meshheading:7691245-Histiocytoma, Benign Fibrous, pubmed-meshheading:7691245-Humans, pubmed-meshheading:7691245-Immunohistochemistry, pubmed-meshheading:7691245-Inflammation, pubmed-meshheading:7691245-Insulin-Like Growth Factor I, pubmed-meshheading:7691245-Interferon-alpha, pubmed-meshheading:7691245-Interleukins, pubmed-meshheading:7691245-Leukemia, pubmed-meshheading:7691245-Male, pubmed-meshheading:7691245-Middle Aged, pubmed-meshheading:7691245-Retroperitoneal Neoplasms, pubmed-meshheading:7691245-Stem Cell Factor
pubmed:year
1993
pubmed:articleTitle
Cytokines in inflammatory malignant fibrous histiocytoma presenting with leukemoid reaction.
pubmed:affiliation
Department of Pathology, University of Pittsburgh School of Medicine, PA.
pubmed:publicationType
Journal Article, Case Reports, Research Support, Non-U.S. Gov't