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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6443
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pubmed:dateCreated |
1993-10-12
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pubmed:databankReference |
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pubmed:abstractText |
To identify cell adhesion molecules required for angiogenesis, we used an in vitro model in which bovine capillary endothelial cells can be induced to form capillary-like tubes. Monoclonal antibodies directed against the carbohydrate epitopes sialyl Lewis-X and sialyl Lewis-A inhibited capillary formation. We postulated that a member of the selectin family of adhesion molecules may be involved in capillary formation because these proteins bind to sialyl Lewis-X/A-containing ligands. We isolated a 2.8-kilobase complementary DNA from a bovine capillary endothelial cell cDNA library which encodes a polypeptide with 71% identity to human E-selectin. We report here that antibody directed against the bovine E-selectin inhibited capillary formation, suggesting that in addition to its role in leukocyte adhesion to endothelium, a form of E-selectin is involved in capillary morphogenesis.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
365
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
267-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7690465-Amino Acid Sequence,
pubmed-meshheading:7690465-Animals,
pubmed-meshheading:7690465-Blotting, Northern,
pubmed-meshheading:7690465-Capillaries,
pubmed-meshheading:7690465-Carbohydrate Sequence,
pubmed-meshheading:7690465-Cattle,
pubmed-meshheading:7690465-Cell Adhesion Molecules,
pubmed-meshheading:7690465-E-Selectin,
pubmed-meshheading:7690465-Endothelium, Vascular,
pubmed-meshheading:7690465-Glycoconjugates,
pubmed-meshheading:7690465-Humans,
pubmed-meshheading:7690465-Immunologic Techniques,
pubmed-meshheading:7690465-Lewis Blood-Group System,
pubmed-meshheading:7690465-Molecular Sequence Data,
pubmed-meshheading:7690465-RNA, Messenger,
pubmed-meshheading:7690465-Sequence Homology, Amino Acid
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pubmed:year |
1993
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pubmed:articleTitle |
A role for sialyl Lewis-X/A glycoconjugates in capillary morphogenesis.
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pubmed:affiliation |
Surgical Research Laboratory, Children's Hospital, Boston, Massachusetts 02115.
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pubmed:publicationType |
Journal Article,
In Vitro
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