Linked Life Data

7689511

Source:http://linkedlifedata.com/resource/pubmed/id/7689511

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1993-9-30
pubmed:abstractText
To determine whether detection of IgM type antibody (Ab) to hepatitis C virus (HCV) antigens would be useful in the early diagnosis of type C acute hepatitis (AH) or fulminant hepatitis (FH), we assayed serum IgM and IgG type Abs to nonstructural (C100-3) and core (AR 142) antigens of HCV in patients with type C hepatitis. Of 8 patients with AH, anti-C100-3 IgM and anti-AR 142 IgM were positive in 1 and 6 patients, respectively. Early appearance of Anti-AR 142 IgM was observed in all of these 6 patients, and in 4 anti-AR 142 IgM was the sole serological marker of HCV infection during the acute-phase. However, the anti-AR 142 IgM response was rather persistent, not transient in AH. Only 1 patient with AH was positive for anti-C100-3 IgM, and this patient became positive for anti-AR 142 IgM 3 months before the appearance of anti-C100-3 IgM. The titre of anti-AR 142 IgM in AH was not dependent on the activity of hepatitis or on the duration. Anti-AR 142 IgM was also positive in 30-75% cases with chronic HCV carriers. Thus it is suggested that the detection of anti-AR 142 IgM may contribute to the early diagnosis of type C AH, although the appearance of this marker in chronic HCV carriers limits its usefulness as the sole serological marker of acute HCV infection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0435-1339
pubmed:author
pubmed:issnType
Print
pubmed:volume
28 Suppl 5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
71-5
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Anti-HCV immunoglobulin M antibody in patients with acute and fulminant hepatitis C.
pubmed:affiliation
Third Department of Internal Medicine, Ehime University School of Medicine, Japan.
pubmed:publicationType
Journal Article