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| pubmed-article:7689152 | lifeskim:mentions | umls-concept:C1524073 | lld:lifeskim |
| pubmed-article:7689152 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
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| pubmed-article:7689152 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:7689152 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:7689152 | pubmed:dateCreated | 1993-9-23 | lld:pubmed |
| pubmed-article:7689152 | pubmed:abstractText | Genes which mediate odorant signal transduction are expressed at high levels in neurons of the olfactory epithelium. The molecular mechanism governing the restricted expression of these genes likely involves tissue-specific DNA binding proteins which coordinately activate transcription through sequence-specific interactions with olfactory promoter regions. We have identified binding sites for the olfactory neuron-specific transcription factor, Olf-1, in the sequences surrounding the transcriptional initiation site of five olfactory neuron-specific genes. The Olf-1 binding sites described define the consensus sequence YTCCCYRGGGAR. In addition, we have identified a second binding site, the U site, in the olfactory cyclic nucleotide gated channel and type III cyclase promoters, which binds factors present in all tissue examined. These experiments support a model in which expression of Olf-1 in the sensory neurons coordinately activates a set of olfactory neuron-specific genes. Furthermore, expression of a subset of these genes may be modulated by additional binding factors. | lld:pubmed |
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| pubmed-article:7689152 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7689152 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7689152 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7689152 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7689152 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7689152 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:7689152 | pubmed:author | pubmed-author:SPERJ RJR | lld:pubmed |
| pubmed-article:7689152 | pubmed:author | pubmed-author:SchraderK AKA | lld:pubmed |
| pubmed-article:7689152 | pubmed:author | pubmed-author:UcakAA | lld:pubmed |
| pubmed-article:7689152 | pubmed:author | pubmed-author:TsaiR YRY | lld:pubmed |
| pubmed-article:7689152 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7689152 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:7689152 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7689152 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7689152 | pubmed:pagination | 5805-13 | lld:pubmed |
| pubmed-article:7689152 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7689152 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7689152 | pubmed:articleTitle | Genes encoding components of the olfactory signal transduction cascade contain a DNA binding site that may direct neuronal expression. | lld:pubmed |
| pubmed-article:7689152 | pubmed:affiliation | Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, Maryland 21205-2185. | lld:pubmed |
| pubmed-article:7689152 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7689152 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7689152 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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