Linked Life Data

7688850

Source:http://linkedlifedata.com/resource/pubmed/id/7688850

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1993-9-14
pubmed:abstractText
A search for control mechanisms involving embryonic genes is explored reviewing a variety of subject areas including, a) the methylation status of DNA and the globin gene, b) ethionine and steroid effects on expression of embryonic genes, c) alpha-fetoprotein gene activity induced by carcinogens and in hepatomas. Also taken into account are transcriptional and cytogenetic aspects. Theories of heterochromatin dynamics are developed in connection with certain contributions from chromatin experimental findings, especially regarding the status of methylation. The potential importance to control theory of the inverse correlation between ATP:L-methionine S-adenosyltransferase activity and alpha-fetoprotein synthesis is emphasized. Several generalizations were derived during the study. It appears that the depression mechanisms may act only on genes that have been active in embryonic stages and have become repressed during differentiation. Another idea concerned heterochromatin. Any heterochromatic segment of DNA may represent at its associated ends a certain amount of euchromatin that would be in a quasi-heterochromatic state. Such pseudoheterochromatin is hypothesized to be induced by the true heterochromatin (eigenheterochromatin).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0306-9877
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
287-95
pubmed:dateRevised
2008-8-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Biochemical formulations of embryonic gene control.
pubmed:affiliation
Canadian Institute of Theoretical Biology, Nova Scotia.
pubmed:publicationType
Journal Article