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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1993-9-15
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pubmed:abstractText |
Human anti-La/SS-B autoantibodies are known to react with highly conserved epitopes suggested to be functional or active sites on the La/SS-B polypeptide. This study was designed to determine whether the autoantibodies also react with poorly conserved regions of La/SS-B as predicted by an antigen-driven autoimmune response. Binding of human autoantibodies to purified human, mouse, and bovine recombinant fragments representing immunodominant regions of the La/SS-B polypeptide was compared using Western blotting and ELISA. A cross-reactive epitope was located in the highly conserved NH2-terminal region of La/SS-B. Significantly, human-specific epitopes were identified in both the conserved RNA-recognition motif and a poorly conserved COOH-terminal fragment, providing direct evidence for an autoantigen-driven response. The lack of autoantibody cross-reactivity with a conserved domain of mouse and bovine La/SS-B implies that a small number of residues in human autoepitopes may be critical for autoimmunogenicity.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688758-1373498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688758-1373741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688758-1376123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688758-1522245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688758-1688881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688758-1692037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688758-1700996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688758-1701785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688758-1716540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688758-1833722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688758-2033256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688758-2445893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688758-2448875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688758-2461985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688758-2464497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688758-2468131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688758-2472427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688758-2473859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688758-2646863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688758-3162770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688758-3192525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688758-3280680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688758-3486661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688758-6607117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7688758-8454877
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1104-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7688758-Amino Acid Sequence,
pubmed-meshheading:7688758-Animals,
pubmed-meshheading:7688758-Autoantibodies,
pubmed-meshheading:7688758-Autoantigens,
pubmed-meshheading:7688758-Cattle,
pubmed-meshheading:7688758-Conserved Sequence,
pubmed-meshheading:7688758-Epitopes,
pubmed-meshheading:7688758-Humans,
pubmed-meshheading:7688758-Mice,
pubmed-meshheading:7688758-Molecular Sequence Data,
pubmed-meshheading:7688758-Polymerase Chain Reaction,
pubmed-meshheading:7688758-Recombinant Fusion Proteins,
pubmed-meshheading:7688758-Ribonucleoproteins,
pubmed-meshheading:7688758-Sequence Homology, Amino Acid
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pubmed:year |
1993
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pubmed:articleTitle |
Identification of a human-specific epitope in a conserved region of the La/SS-B autoantigen.
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pubmed:affiliation |
Department of Clinical Immunology, Flinders Medical Centre, Bedford Park, South Australia.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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