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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1993-9-14
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pubmed:abstractText |
Forty-eight patients with non-resectable cancer of the oesophagus and oesophagogastric junction (group A: Stage I/II: n = 32; group B: Stage III/IV: n = 16) underwent intralumenal iridium-192 high dose-rate afterloading brachytherapy (5-7 Gy/session, total dose 5-21 Gy, mean 12.4 Gy) and external beam irradiation (Karnofsky > or = 80%: 50-60 Gy/2 Gy per day; Karnofsky 60%-79%: 30 Gy/3 per day). Prolonged satisfactory palliation (intake of at least semi-solid food) was demonstrated in 96% of patients. The mean survival for group A was 19.1 months and that for group B 6.9 months, with a 12-month survival rate of 66% for group A and 0% for group B (P < 0.001). Local tumour response and complication rate were significantly dose related with a predicted response rate of 70.5% and a complication rate of 50% at extrapolated response dose (ERD) 129.3 GY3 (Gy at alpha/beta = 3).
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0936-6555
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
154-8
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pubmed:dateRevised |
2008-3-10
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pubmed:meshHeading |
pubmed-meshheading:7688549-Adult,
pubmed-meshheading:7688549-Aged,
pubmed-meshheading:7688549-Aged, 80 and over,
pubmed-meshheading:7688549-Brachytherapy,
pubmed-meshheading:7688549-Esophageal Neoplasms,
pubmed-meshheading:7688549-Female,
pubmed-meshheading:7688549-Humans,
pubmed-meshheading:7688549-Iridium Radioisotopes,
pubmed-meshheading:7688549-Male,
pubmed-meshheading:7688549-Middle Aged,
pubmed-meshheading:7688549-Palliative Care,
pubmed-meshheading:7688549-Radiotherapy Dosage,
pubmed-meshheading:7688549-Survival Rate
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pubmed:year |
1993
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pubmed:articleTitle |
Iridium-192 high dose rate brachytherapy combined with external beam irradiation in non-resectable oesophageal cancer.
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pubmed:affiliation |
Department of Radiotherapy, University of Graz, Austria.
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pubmed:publicationType |
Journal Article
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