Linked Life Data

7687556

Source:http://linkedlifedata.com/resource/pubmed/id/7687556

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1993-8-26
pubmed:abstractText
Recently urologists have focused their attention not only on classical evaluation parameters for patients suffering from benign prostatic hyperplasia (BPH), such as symptoms and uroflowmetry, but also on the impact of therapy on the patients' quality of life. An observational, open-label, uncontrolled trial was designed to evaluate the impact of a 3-month therapy with alfuzosin (2.5 mg t.i.d.) on the quality of life of patients complaining of BPH-related symptoms for at least 6 months. Nine hundred and ninety patients were enrolled in 86 Italian centers of urology. At baseline and after 84 days of treatment the following assessments were performed: the Maine Medical Assessment Program Symptom Score, a quality of life questionnaire, and at selected centers, uroflowmetry and residual volume measurement. Preliminary results on 498 evaluable patients (who completed the study by March 1992), showed the ability of alfuzosin to improve BPH symptoms significantly (total mean score from 12.02 +/- 0.17 to 7.27 +/- 0.12, -39.5%), mostly in patients with severe symptoms at baseline (-46.8%). All the three indices describing patients' quality of life improved significantly: mental health +2.3% (p < 0.01); general health +4.3% (p < 0.01), and especially, activity +12.9% (p < 0.01). A marked improvement was observed in patients with severe symptoms (activity index +23.8%). Uroflowmetric data obtained from 255 patients showed a significant increase in peak (+4.14 ml/s) and mean (+2.58 ml/s) flows, associated with a marked decrease in residual volume (-34.1 ml, -52.6%). Thirty-three patients experienced one or more adverse medical events, mainly within the first 4 weeks of treatment (20 patients).(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0302-2838
pubmed:author
pubmed:issnType
Print
pubmed:volume
24 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
28-33
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Effect of alfuzosin on quality of life in benign prostatic hyperplasia patients: preliminary results. Italian Alfuzosin Co-Operative Group.
pubmed:affiliation
Urology Department, University Bologna, Italy.
pubmed:publicationType
Journal Article, Clinical Trial, Multicenter Study