Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1993-7-27
|
| pubmed:abstractText |
During an 8-year prospective study of post-transfusion hepatitis conducted at the Thalassemic Center of Cagliari (Italy), including 135 newly diagnosed thalassemic children on long-term transfusion maintenance, 83 children (61%) developed non-A, non-B hepatitis (NANBH). Resolution of NANBH was observed in 17 (20%) cases, and chronicity in 57 (69%), whereas the remaining 9 (11%) experienced one or two additional bouts of acute NANBH. Of the 83 children with NANBH, 75 (90%) showed anti-hepatitis C virus (HCV) seroconversion when tested by second-generation enzyme-linked immunosorbent assay (ELISA), whereas first-generation ELISA showed anti-HCV in only 59 (71%) cases (p = 0.003). Moreover, the newly developed assay allowed an earlier detection of anti-HCV response in most of the patients who seroconverted by both assays, reducing significantly the mean onset-seroconversion interval (5 +/- 9.4 weeks vs. 14.5 +/- 20.8 weeks, p < 0.05). It was significantly more sensitive for the identification of HCV infection, not only in resolving NANBH, but also in NANBH progressing to chronicity (79 vs. 35%, respectively, p = 0.008; and 93 vs. 79%, p = 0.028). The pattern of antibody response with first-generation assay was characterized by clearance of anti-HCV with time, in most of the patients who recovered, and by persistence of anti-HCV in the majority of those who progressed to chronicity, whereas second-generation ELISA usually showed persistence of anti-HCV over time, regardless to the outcome of the disease.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0277-2116
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
458-64
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7686220-Acute Disease,
pubmed-meshheading:7686220-Alanine Transaminase,
pubmed-meshheading:7686220-Blood Component Transfusion,
pubmed-meshheading:7686220-Chi-Square Distribution,
pubmed-meshheading:7686220-Child, Preschool,
pubmed-meshheading:7686220-Chronic Disease,
pubmed-meshheading:7686220-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:7686220-Female,
pubmed-meshheading:7686220-Follow-Up Studies,
pubmed-meshheading:7686220-Hepacivirus,
pubmed-meshheading:7686220-Hepatitis Antibodies,
pubmed-meshheading:7686220-Hepatitis C,
pubmed-meshheading:7686220-Hepatitis C Antibodies,
pubmed-meshheading:7686220-Humans,
pubmed-meshheading:7686220-Infant,
pubmed-meshheading:7686220-Male,
pubmed-meshheading:7686220-Prospective Studies,
pubmed-meshheading:7686220-Sensitivity and Specificity,
pubmed-meshheading:7686220-beta-Thalassemia
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Evaluation of antibodies to hepatitis C virus in a long-term prospective study of posttransfusion hepatitis among thalassemic children: comparison between first- and second-generation assay.
|
| pubmed:affiliation |
Institute of Internal Medicine, University of Cagliari, Italy.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|