Linked Life Data

7684591

Source:http://linkedlifedata.com/resource/pubmed/id/7684591

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1993-6-30
pubmed:abstractText
Proliferative sites within the overgrowing epithelium of cholesteatoma are still ill defined. In this study, we used the monoclonal antibody Ki-67 on frozen cut sections from 23 cholesteatoma samples obtained at surgery from 20 patients. This reagent has been reported to stain the nucleus of proliferating tumor cells and the cytoplasm of growing keratinocytes. In this series of samples, flat superficial layers of epithelium were consistently negative for Ki-67 or displayed a faint staining of the basal layer. By contrast, the deepest areas of epithelial recesses appeared brightly stained with Ki-67. The latter were often in the close vicinity of inflammatory cells present in the underlying mucosa. This observation suggests that cholesteatoma growth is initiated within the deep epithelial folds of overgrown tympanic skin, and that it might be triggered or sustained by inflammatory cytokines.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0886-4470
pubmed:author
pubmed:issnType
Print
pubmed:volume
119
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
656-8
pubmed:dateRevised
2006-3-28
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Restricted expression of Ki-67 in cholesteatoma epithelium.
pubmed:affiliation
Otorhinolaryngology Clinic, Centre Hospitalier Universitaire and Universitaire de Nancy, Vandoeuvre les Nancy, France.
pubmed:publicationType
Journal Article