| pubmed-article:7684399 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7684399 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:7684399 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:7684399 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:7684399 | lifeskim:mentions | umls-concept:C0017071 | lld:lifeskim |
| pubmed-article:7684399 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:7684399 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:7684399 | lifeskim:mentions | umls-concept:C0391754 | lld:lifeskim |
| pubmed-article:7684399 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7684399 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:7684399 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:7684399 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7684399 | pubmed:dateCreated | 1993-6-22 | lld:pubmed |
| pubmed-article:7684399 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684399 | pubmed:abstractText | Interleukin-1 (IL-1) induces substance P (SP) gene expression in cultured rat superior cervical ganglion (SCG) explants. In order to study the molecular mechanism of this action of IL-1, the presence of an interleukin-1 receptor (IL-1R) activity and the identity of an mRNA homologous to known IL-1R sequence was determined in SCG. The SP increase is blocked by recombinant IL-1 receptor antagonist protein, so IL-1 must be interacting with a specific receptor. We have cloned cDNA homologous to IL-1R type I from rat SCG using a reverse transcription-polymerase chain reaction (RT-PCR). The resulting cDNA sequence is strongly homologous with mouse and human IL-1R cDNA of the T cell and fibroblast type (type I; encoding an 80-kDa protein). mRNA specific for IL-1R can be readily detected in intact SCG by quantitative RT-PCR and S1 hybridization. However, the level of IL-1R mRNA increases 3-6-fold by 2 days in culture. This increase is independent of the presence of dexamethasone, IL-1 beta or IL-1 receptor antagonist protein ligands. The increase of IL-1R following explantation, a model of nerve injury, may provide a mechanism linking inflammatory signalling to neuronal phenotypic changes. | lld:pubmed |
| pubmed-article:7684399 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684399 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7684399 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684399 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7684399 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684399 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684399 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684399 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684399 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684399 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684399 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684399 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7684399 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7684399 | pubmed:issn | 0165-5728 | lld:pubmed |
| pubmed-article:7684399 | pubmed:author | pubmed-author:LisMM | lld:pubmed |
| pubmed-article:7684399 | pubmed:author | pubmed-author:JonakaitG MGM | lld:pubmed |
| pubmed-article:7684399 | pubmed:author | pubmed-author:McCormackR... | lld:pubmed |
| pubmed-article:7684399 | pubmed:author | pubmed-author:HartR PRP | lld:pubmed |
| pubmed-article:7684399 | pubmed:author | pubmed-author:ShadiackA MAM | lld:pubmed |
| pubmed-article:7684399 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7684399 | pubmed:volume | 44 | lld:pubmed |
| pubmed-article:7684399 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7684399 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7684399 | pubmed:pagination | 49-56 | lld:pubmed |
| pubmed-article:7684399 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7684399 | pubmed:meshHeading | pubmed-meshheading:7684399-... | lld:pubmed |
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| pubmed-article:7684399 | pubmed:meshHeading | pubmed-meshheading:7684399-... | lld:pubmed |
| pubmed-article:7684399 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7684399 | pubmed:articleTitle | An mRNA homologous to interleukin-1 receptor type I is expressed in cultured rat sympathetic ganglia. | lld:pubmed |
| pubmed-article:7684399 | pubmed:affiliation | Department of Biological Sciences, Rutgers University, Newark, NJ 07102. | lld:pubmed |
| pubmed-article:7684399 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7684399 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7684399 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:7684399 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:25663 | entrezgene:pubmed | pubmed-article:7684399 | lld:entrezgene |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7684399 | lld:pubmed |
