| pubmed-article:7684386 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7684386 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
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| pubmed-article:7684386 | lifeskim:mentions | umls-concept:C1334087 | lld:lifeskim |
| pubmed-article:7684386 | lifeskim:mentions | umls-concept:C0292863 | lld:lifeskim |
| pubmed-article:7684386 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:7684386 | lifeskim:mentions | umls-concept:C1444748 | lld:lifeskim |
| pubmed-article:7684386 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:7684386 | lifeskim:mentions | umls-concept:C2611253 | lld:lifeskim |
| pubmed-article:7684386 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:7684386 | lifeskim:mentions | umls-concept:C0439836 | lld:lifeskim |
| pubmed-article:7684386 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:7684386 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:7684386 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7684386 | pubmed:dateCreated | 1993-6-21 | lld:pubmed |
| pubmed-article:7684386 | pubmed:abstractText | The monoclonal antibody 33B6 was found to be specific for the beta 1 integrin subunit. Treatment of leukocytes with this antibody induced a vigorous homotypic aggregation that had similar physiologic conditions as aggregation induced by a monoclonal antibody specific for the alpha 4 subunit. Expression of a beta 1 subunit on the cell surface was not sufficient for mAb 33B6-mediated aggregation to occur, since cells of the K562 erythroleukemia line failed to respond even though they expressed the beta 1 subunit and the 33B6 epitope. However, after transfection with cDNA encoding the alpha 4 subunit, K562 cells acquired the ability to aggregate in response to mAb 33B6 binding. By contrast, mAb 33B6 blocked cell binding to the endothelial surface protein vascular cell adhesion molecule-1 and the extracellular matrix protein fibronectin. These results suggest that the beta 1 epitope defined by mAb 33B6 may play a novel role in regulating leukocyte adhesive interactions. | lld:pubmed |
| pubmed-article:7684386 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7684386 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684386 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7684386 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7684386 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7684386 | pubmed:issn | 0730-2312 | lld:pubmed |
| pubmed-article:7684386 | pubmed:author | pubmed-author:RenzMM | lld:pubmed |
| pubmed-article:7684386 | pubmed:author | pubmed-author:FongSS | lld:pubmed |
| pubmed-article:7684386 | pubmed:author | pubmed-author:BednarczykJ... | lld:pubmed |
| pubmed-article:7684386 | pubmed:author | pubmed-author:McIntyreB WBW | lld:pubmed |
| pubmed-article:7684386 | pubmed:author | pubmed-author:SzaboM CMC | lld:pubmed |
| pubmed-article:7684386 | pubmed:author | pubmed-author:WygantJ NJN | lld:pubmed |
| pubmed-article:7684386 | pubmed:author | pubmed-author:Molinari-Stor... | lld:pubmed |
| pubmed-article:7684386 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7684386 | pubmed:volume | 51 | lld:pubmed |
| pubmed-article:7684386 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7684386 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7684386 | pubmed:pagination | 465-78 | lld:pubmed |
| pubmed-article:7684386 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7684386 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7684386 | pubmed:articleTitle | Homotypic leukocyte aggregation triggered by a monoclonal antibody specific for a novel epitope expressed by the integrin beta 1 subunit: conversion of nonresponsive cells by transfecting human integrin alpha 4 subunit cDNA. | lld:pubmed |
| pubmed-article:7684386 | pubmed:affiliation | Department of Immunology, University of Texas M.D. Anderson Cancer Center, Houston 77030. | lld:pubmed |
| pubmed-article:7684386 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7684386 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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