Linked Life Data

7683595

Source:http://linkedlifedata.com/resource/pubmed/id/7683595

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-6-10
pubmed:abstractText
Treatment with 5-azadeoxycytidine (5-aza-dC) causes dramatic inhibition of mitotic condensation in the inactive X chromosome, without affecting the active X chromosome and autosomes. The undercondensed chromatin structure is most prominent in the late-replicating regions of the inactive X chromosome, whereas specific earlier-replicating segments on the inactive X probably associated with large blocks of genes that escape inactivation remain normally condensed. This segmentation of inactive X chromosomes has been evolutionarily conserved and is unique to mammals. It suggests temporal or mechanistic separation in condensation of inactive X chromatin. Condensation of chromatin structure is a novel and general feature of inactive X chromosomes that may be involved, directly or indirectly, in the maintenance and stabilization of X inactivation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0301-0171
pubmed:author
pubmed:issnType
Print
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
160-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
5-Azadeoxycytidine distinguishes between active and inactive X chromosome condensation.
pubmed:affiliation
Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510-8005.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't