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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1993-6-1
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pubmed:abstractText |
The cDNAs encoding Xenopus laevis prolactin (PRL) and the alpha and beta subunits of thyroid-stimulating hormone (TSH alpha and TSH beta, respectively) have been cloned from a pituitary library. Results of developmental RNA blot analysis contradict the long-held biological role for PRL as a juvenilizing hormone in amphibia. The pituitary gland of a premetamorphic tadpole expresses PRL mRNA at very low levels. The abundance of PRL mRNA increases late in metamorphosis as a response to thyroid hormone (TH), suggesting that PRL is more likely to have a function in the frog than in the tadpole. TSH alpha and -beta mRNA levels increase through prometamorphosis; this rise does not appear to be regulated directly by TH. At climax, both TH and TSH mRNA levels drop. The sequential morphological changes that characterize prometamorphosis depend upon the gradual increase of endogenous TH, which peaks at climax. This increase in TH in turn depends upon the lack of a traditional thyroid-pituitary negative-feedback loop throughout prometamorphosis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7683408-2188653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7683408-2288640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7683408-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7683408-2734108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7683408-301839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7683408-302813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7683408-3162770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7683408-3491019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7683408-3973558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7683408-6079933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7683408-6177696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7683408-6199191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7683408-6325416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7683408-6345149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7683408-6774912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7683408-6804283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7683408-805743
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3820-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7683408-Animals,
pubmed-meshheading:7683408-Base Sequence,
pubmed-meshheading:7683408-Blotting, Southern,
pubmed-meshheading:7683408-DNA,
pubmed-meshheading:7683408-Embryo, Nonmammalian,
pubmed-meshheading:7683408-Gene Expression,
pubmed-meshheading:7683408-Gene Expression Regulation,
pubmed-meshheading:7683408-Gene Library,
pubmed-meshheading:7683408-Metamorphosis, Biological,
pubmed-meshheading:7683408-Methimazole,
pubmed-meshheading:7683408-Pituitary Gland,
pubmed-meshheading:7683408-Prolactin,
pubmed-meshheading:7683408-RNA,
pubmed-meshheading:7683408-RNA, Messenger,
pubmed-meshheading:7683408-Thyroid Hormones,
pubmed-meshheading:7683408-Thyrotropin,
pubmed-meshheading:7683408-Xenopus laevis
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pubmed:year |
1993
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pubmed:articleTitle |
Expression of the Xenopus laevis prolactin and thyrotropin genes during metamorphosis.
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pubmed:affiliation |
Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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