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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1993-5-26
|
| pubmed:abstractText |
To assess the role of hepatitis C virus (HCV) in liver disease in Somalia, antibody to HCV (anti-HCV) was studied by enzyme-linked immunosorbent assay (ELISA) and recombinant immunoblot assay (RIBA) in 110 patients with chronic liver diseases, in 309 healthy adults, in 179 institutionalized subjects with a high prevalence of intestinal parasites and Schistosoma haematobium, and in 287 children with diseases other than hepatitis. According to the RIBA test, anti-HCV was present in three healthy adults (0.97%), in four institutionalized individuals (2.2%), but in none of the children. The prevalence of anti-HCV was 4.8% in patients with hepatitis B surface antigen (HBsAg)-positive chronic liver diseases and 20.6% in patients with HBsAg-negative chronic liver diseases. Thus, HCV infection appears to play a minor role in HBsAg-positive liver disease in Somalia but may be an important factor in HBsAg-negative chronic liver disease. The low anti-HCV prevalence in individuals with no hepatic disorders is consistent with the fact that HCV does not spread by nonpercutaneous transfer. We found also a large proportion of both patients with hepatic disease and institutionalized individuals who tested positive by ELISA but not confirmed by RIBA. However, the likelihood of a true positive result increases proportionally with the ELISA value; thus, in most cases a low ELISA value probably represents a false-positive reaction, while a high ELISA value probably represents a true positive reaction.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0002-9637
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
48
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
581-4
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7683179-Adult,
pubmed-meshheading:7683179-Child, Preschool,
pubmed-meshheading:7683179-Chronic Disease,
pubmed-meshheading:7683179-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:7683179-Female,
pubmed-meshheading:7683179-Hepacivirus,
pubmed-meshheading:7683179-Hepatitis Antibodies,
pubmed-meshheading:7683179-Hepatitis B Surface Antigens,
pubmed-meshheading:7683179-Hepatitis C,
pubmed-meshheading:7683179-Hepatitis C Antibodies,
pubmed-meshheading:7683179-Humans,
pubmed-meshheading:7683179-Immunoblotting,
pubmed-meshheading:7683179-Infant,
pubmed-meshheading:7683179-Liver Diseases,
pubmed-meshheading:7683179-Male,
pubmed-meshheading:7683179-Middle Aged,
pubmed-meshheading:7683179-Prevalence,
pubmed-meshheading:7683179-Somalia
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Hepatitis C virus infection in chronic liver disease in Somalia.
|
| pubmed:affiliation |
Institute of the Clinic of Tropical and Infectious Disease, La Sapienza University, Rome, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|