Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1993-5-17
pubmed:abstractText
The presence of mRNAs encoding neurotransmitter receptors and voltage-gated channels in the adult human and bovine corpus callosum was investigated using Xenopus oocytes. Oocytes injected with mRNA extracted from the corpus callosum expressed functional receptors to glutamate, acetylcholine, and serotonin, and also voltage-operated Ca2+ channels, all with similar properties in the two species studied. Acetylcholine and serotonin elicited oscillatory Cl- currents due to activation of the inositol phosphate-Ca2+ receptor-channel coupling system. Glutamate and its analogs N-methyl-D-aspartate (NMDA), kainate, quisqualate, and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) induced smooth currents. The non-NMDA responses showed a strong inward rectification at positive potentials and were potently blocked by 6,7-dinitroquinoxaline-2,3-dione, as observed for the AMPA/kainate glutamate receptors GLUR1 and GLUR3. Furthermore, in situ hybridization experiments showed that GLUR1 and GLUR3 mRNAs are present in corpus callosum cells that were labeled with antiserum to glial fibrillary acid protein and that, in primary cell cultures, had the morphology of type 2 astrocytes. These results indicate that glial cells in the adult corpus callosum possess mRNA encoding functional neurotransmitter receptors and Ca2+ channels. These molecules may provide a mechanism for glial-neuronal interactions.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-1317969, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-1317970, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-1348526, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-1348861, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-1351952, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-1353854, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-1374462, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-1648187, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-1653320, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-1691005, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-1699567, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-1705710, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-1709304, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-1720814, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-2168579, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-234273, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-2440339, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-2471080, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-2480522, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-2540340, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-2558177, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-2852639, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-2863826, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-2905459, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-2905791, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-2976037, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-3264676, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-3531873, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-4512407, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-5547254, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-6127718, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-6145158, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-6151179, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-6323990, http://linkedlifedata.com/resource/pubmed/commentcorrection/7682696-7131311
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antisense Elements (Genetics), http://linkedlifedata.com/resource/pubmed/chemical/Aspartic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers, http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels, http://linkedlifedata.com/resource/pubmed/chemical/Glial Fibrillary Acidic Protein, http://linkedlifedata.com/resource/pubmed/chemical/Glutamates, http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Glycine, http://linkedlifedata.com/resource/pubmed/chemical/Ibotenic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Kainic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Quisqualic Acid, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/RNA Probes, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Glutamate, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Kainic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neurotransmitter, http://linkedlifedata.com/resource/pubmed/chemical/alpha-Amino-3-hydroxy-5-methyl-4-iso...
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3270-4
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:7682696-Humans, pubmed-meshheading:7682696-Animals, pubmed-meshheading:7682696-Aged, pubmed-meshheading:7682696-Cattle, pubmed-meshheading:7682696-Aspartic Acid, pubmed-meshheading:7682696-Glutamic Acid, pubmed-meshheading:7682696-Glycine, pubmed-meshheading:7682696-Corpus Callosum, pubmed-meshheading:7682696-Female, pubmed-meshheading:7682696-Male, pubmed-meshheading:7682696-Glutamates, pubmed-meshheading:7682696-Adult, pubmed-meshheading:7682696-Xenopus, pubmed-meshheading:7682696-Astrocytes, pubmed-meshheading:7682696-Middle Aged, pubmed-meshheading:7682696-Membrane Potentials, pubmed-meshheading:7682696-RNA, Messenger, pubmed-meshheading:7682696-Oocytes, pubmed-meshheading:7682696-Biological Markers, pubmed-meshheading:7682696-Receptors, Neurotransmitter, pubmed-meshheading:7682696-Ibotenic Acid
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