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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5104
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pubmed:dateCreated |
1993-4-30
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pubmed:abstractText |
Cytotoxic T lymphocytes (CTLs) control viral infections by recognizing viral peptides presented by major histocompatibility complex (MHC) class I molecules. Human leukocyte antigen (HLA)-A11-restricted CTLs that recognize peptide residues 416 to 424 of the Epstein-Barr virus (EBV) nuclear antigen-4 frequently dominate EBV-induced responses in A11+ Caucasian donors. This epitope is conserved in type A EBV strains from Caucasians and central African populations, where A11 is relatively infrequent. However, strains from highly A11+ populations in New Guinea carry a lysine-to-threonine mutation at residue 424 that abrogates CTL recognition and binding of the peptide to nascent A11 molecules. The results suggest that evolution of a widespread and genetically stable virus such as EBV is influenced by pressure from MHC-restricted CTL responses.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
260
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
98-100
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:7682013-Africa,
pubmed-meshheading:7682013-Antigens, Viral,
pubmed-meshheading:7682013-Cell Line, Transformed,
pubmed-meshheading:7682013-Cell Nucleus,
pubmed-meshheading:7682013-Cell Transformation, Viral,
pubmed-meshheading:7682013-DNA-Binding Proteins,
pubmed-meshheading:7682013-Epitopes,
pubmed-meshheading:7682013-Epstein-Barr Virus Nuclear Antigens,
pubmed-meshheading:7682013-European Continental Ancestry Group,
pubmed-meshheading:7682013-Gene Frequency,
pubmed-meshheading:7682013-HLA-A Antigens,
pubmed-meshheading:7682013-HLA-A11 Antigen,
pubmed-meshheading:7682013-Herpesvirus 4, Human,
pubmed-meshheading:7682013-Humans,
pubmed-meshheading:7682013-New Guinea,
pubmed-meshheading:7682013-Point Mutation,
pubmed-meshheading:7682013-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:7682013-Transfection
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pubmed:year |
1993
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pubmed:articleTitle |
HLA-A11 epitope loss isolates of Epstein-Barr virus from a highly A11+ population.
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pubmed:affiliation |
Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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