Linked Life Data

7681884

Source:http://linkedlifedata.com/resource/pubmed/id/7681884

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-4-30
pubmed:abstractText
HCV genomes are considerable heterogeneities in nucleotide and amino acid sequences among individual isolates. The primary structure of the putative core and NS3 protein regions are relatively conserved among HCV isolates, while those of envelope proteins (E1 and E2) and NS4 are variable. On the basis of nucleotide sequence homology of parts of HCV genomes, several research groups have reported the possible existence of multiple subtypes of HCV isolates. From comparative sequence studies on HCV cDNA clones corresponding to NS3 and NS4 regions followed by diagnostic studies using these clones, have shown that there are at least two groups of HCV, group I and group II. The peptide produced in E. coli, carrying group I and II cDNA clones (A.A. positions 1676-1736 of NS4 region) are recognized by circulating antibodies specific to group I and II HCV. These group specific antigens of NS4 region are highly reliable in detecting (over 90%) circulating antibodies against either groups of HCV. In this study, most of the HCV isolates used were shown to be classified into group I or II HCV based on their amino acid differences and phylogenic analysis within the putative 5'UTR, core and NS3-4 regions. Biological significance of these two groups of HCV is suggested by the observation that the group I HCV was resistance to the IFN therapy (10-20% showing a good response), on the other hand the group II HCV showed a good response (70-90%).
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0047-1852
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
338-43
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
[Antigenicities of groups I and II hepatitis C virus].
pubmed:affiliation
Department of Microbiology, Tokyo Metropolitan Institute of Medical Science.
pubmed:publicationType
Journal Article, English Abstract, Review