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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5102
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pubmed:dateCreated |
1993-4-20
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pubmed:databankReference |
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pubmed:abstractText |
Tyrosine phosphorylation of proteins is required for signal transduction in cells and for growth regulation. A mitogen-induced gene (PAC-1) has been cloned from human T cells and encodes a 32-kilodalton protein that contains a sequence that defines the enzymatic site of known protein phosphotyrosine phosphatases (PTPases). Other than this sequence, PAC-1 is different from several other known related PTPases exemplified by PTP-1b. PAC-1 is similar to a phosphatase induced by mitogens or heat shock in fibroblasts, a yeast gene, and a vaccinia virus-encoded serine-tyrosine phosphatase (VH1). PAC-1 was predominantly expressed in hematopoietic tissues and localized to the nucleus in transfected COS-7 cells and in mitogen-stimulated T cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
259
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pubmed:geneSymbol |
PAC-1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1763-6
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:7681221-Amino Acid Sequence,
pubmed-meshheading:7681221-Animals,
pubmed-meshheading:7681221-Blotting, Northern,
pubmed-meshheading:7681221-Cell Line,
pubmed-meshheading:7681221-Cell Nucleus,
pubmed-meshheading:7681221-Conserved Sequence,
pubmed-meshheading:7681221-Cytoplasm,
pubmed-meshheading:7681221-Dual Specificity Phosphatase 2,
pubmed-meshheading:7681221-Fluorescent Antibody Technique,
pubmed-meshheading:7681221-Humans,
pubmed-meshheading:7681221-Immunosorbent Techniques,
pubmed-meshheading:7681221-Mice,
pubmed-meshheading:7681221-Mitogens,
pubmed-meshheading:7681221-Molecular Sequence Data,
pubmed-meshheading:7681221-Organ Specificity,
pubmed-meshheading:7681221-Protein Phosphatase 2,
pubmed-meshheading:7681221-Protein Tyrosine Phosphatases,
pubmed-meshheading:7681221-RNA,
pubmed-meshheading:7681221-Sequence Homology, Amino Acid,
pubmed-meshheading:7681221-Signal Transduction,
pubmed-meshheading:7681221-T-Lymphocytes,
pubmed-meshheading:7681221-Transfection
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pubmed:year |
1993
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pubmed:articleTitle |
PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase.
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pubmed:affiliation |
Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, MD 20892.
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pubmed:publicationType |
Journal Article,
Comparative Study
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