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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1993-4-14
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pubmed:databankReference |
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pubmed:abstractText |
We show that the CHox-cad gene is continuously expressed throughout embryogenesis from Days 1 to 14 of development. In the adult chicken, CHox-cad appears to be expressed exclusively in the gut. Genomic Southern blot hybridization experiments suggest that there may be only a single CHox-cad gene per haploid genome from which RNAs of 2.9 and 1.6 kb are transcribed. In situ hybridization to sections of 80-hr to 12-day chick embryos with a CHox-cad probe reveals that this gene is expressed at high levels in organs of endodermal origin: the developing liver, pancreas, lung, and in the epithelial lining of the entire intestine. By Day 16 of development, CHox-cad signals are observed in the epithelial lining of the gut but no longer in the other endodermally derived organs. The coincidence of CHox-cad expression with the onset of development of these endoderm-derived organs may indicate an important role for that gene during the early steps of organogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0012-1606
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
156
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pubmed:geneSymbol |
CHox-cad
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
155-63
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7680627-Animals,
pubmed-meshheading:7680627-Blotting, Northern,
pubmed-meshheading:7680627-Blotting, Southern,
pubmed-meshheading:7680627-Chick Embryo,
pubmed-meshheading:7680627-Chickens,
pubmed-meshheading:7680627-DNA,
pubmed-meshheading:7680627-Endoderm,
pubmed-meshheading:7680627-Genes, Homeobox,
pubmed-meshheading:7680627-Genome,
pubmed-meshheading:7680627-Genomic Library,
pubmed-meshheading:7680627-Haploidy,
pubmed-meshheading:7680627-In Situ Hybridization,
pubmed-meshheading:7680627-Introns,
pubmed-meshheading:7680627-Molecular Sequence Data,
pubmed-meshheading:7680627-Open Reading Frames,
pubmed-meshheading:7680627-Organ Specificity,
pubmed-meshheading:7680627-Poly A,
pubmed-meshheading:7680627-RNA,
pubmed-meshheading:7680627-RNA, Messenger,
pubmed-meshheading:7680627-Transcription, Genetic
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pubmed:year |
1993
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pubmed:articleTitle |
Continued expression of the chicken caudal homologue in endodermally derived organs.
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pubmed:affiliation |
Institut für Molekularbiologie und Tumorforschung, Philipps-Universität, Marburg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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