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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1993-4-9
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pubmed:abstractText |
Effects of 5-hydroxyindole (5-OHi) on 5-HT3 receptor-operated ion current were investigated in voltage-clamped N1E-115 neuroblastoma cells. In the presence of 1 mM 5-OHi, the amplitudes of inward currents induced by the agonists 5-hydroxytryptamine (5-HT), 2-methyl-5-HT and dopamine were enhanced and desensitization of the responses was markedly slowed down. The results indicate that 5-OHi selectively modifies the desensitization of the 5-HT3 receptor-mediated ion current.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
108
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
287-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1993
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pubmed:articleTitle |
5-Hydroxyindole slows desensitization of the 5-HT3 receptor-mediated ion current in N1E-115 neuroblastoma cells.
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pubmed:affiliation |
Research Institute of Toxicology, Utrecht University, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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