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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5099
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pubmed:dateCreated |
1993-4-8
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pubmed:databankReference |
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pubmed:abstractText |
The glycosylphosphatidylinositol (GPI) anchor is a membrane attachment structure of many proteins and occurs in a wide variety of eukaryotes from yeasts to mammals. The structure of the core of the GPI anchor is conserved in protozoa and mammals and so is its biosynthetic pathway. A complementary DNA encoding a human protein termed PIG-A (phosphatidylinositol glycan-class A) was cloned. PIG-A was necessary for synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD55,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD59,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Thy-1,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Glycosylphosphatidylinositols,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
259
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pubmed:geneSymbol |
PIG-A
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1318-20
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:7680492-Amino Acid Sequence,
pubmed-meshheading:7680492-Animals,
pubmed-meshheading:7680492-Antigens, CD,
pubmed-meshheading:7680492-Antigens, CD55,
pubmed-meshheading:7680492-Antigens, CD59,
pubmed-meshheading:7680492-Antigens, Surface,
pubmed-meshheading:7680492-Antigens, Thy-1,
pubmed-meshheading:7680492-Cloning, Molecular,
pubmed-meshheading:7680492-DNA,
pubmed-meshheading:7680492-Genetic Complementation Test,
pubmed-meshheading:7680492-Glycosylphosphatidylinositols,
pubmed-meshheading:7680492-HeLa Cells,
pubmed-meshheading:7680492-Humans,
pubmed-meshheading:7680492-Membrane Glycoproteins,
pubmed-meshheading:7680492-Membrane Proteins,
pubmed-meshheading:7680492-Mice,
pubmed-meshheading:7680492-Molecular Sequence Data,
pubmed-meshheading:7680492-Solubility,
pubmed-meshheading:7680492-Species Specificity
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pubmed:year |
1993
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pubmed:articleTitle |
The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis.
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pubmed:affiliation |
Department of Immunoregulation, Osaka University, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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