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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1993-4-8
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pubmed:abstractText |
Residues 11 to 27 of the hepatitis B virus nucleocapsid antigen contain a cytotoxic T-cell epitope that is recognized by cytotoxic T cells from virtually all HLA-A2-positive patients with acute hepatitis B virus infection. Using panels of truncated and overlapping peptides, we now show that the optimal amino acid sequence recognized by cytotoxic T cells is a 10-mer (residues 18 to 27) containing the predicted peptide-binding motif for HLA-A2 and that this peptide can stimulate cytotoxic T cells able to recognize endogenously synthesized hepatitis B core antigen. Since patients with chronic hepatitis B virus infection fail to mount an efficient cytotoxic T-cell response to it, this epitope might serve as the starting point for the design of synthetic peptide-based immunotherapeutic strategies to terminate persistent viral infection.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-1313893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-1323877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-1323878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-1375265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-1380181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-1448153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-1546328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-1660137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-1692084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-1700303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-1700304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-1706750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-1708852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-1709722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-1713253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-1720813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-1744592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-1889458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-1922337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-1922338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-1992491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-2038058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-2062379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-2115762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-2157137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-2420472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-2437457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-2443855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-2455012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-2457647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-2535860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-2586628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-2594067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-2685356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-2784478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-2787356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-3309677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7680391-399329
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
2376-80
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7680391-Acute Disease,
pubmed-meshheading:7680391-Amino Acid Sequence,
pubmed-meshheading:7680391-Cytotoxicity, Immunologic,
pubmed-meshheading:7680391-Epitopes,
pubmed-meshheading:7680391-Hepatitis B,
pubmed-meshheading:7680391-Hepatitis B Core Antigens,
pubmed-meshheading:7680391-Hepatitis B virus,
pubmed-meshheading:7680391-Humans,
pubmed-meshheading:7680391-Molecular Sequence Data,
pubmed-meshheading:7680391-Peptides,
pubmed-meshheading:7680391-T-Lymphocytes, Cytotoxic
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pubmed:year |
1993
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pubmed:articleTitle |
Definition of a minimal optimal cytotoxic T-cell epitope within the hepatitis B virus nucleocapsid protein.
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pubmed:affiliation |
Cattedra Malattie Infettive, Università di Parma, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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