| pubmed-article:7679745 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7679745 | lifeskim:mentions | umls-concept:C0014049 | lld:lifeskim |
| pubmed-article:7679745 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:7679745 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
| pubmed-article:7679745 | lifeskim:mentions | umls-concept:C1422036 | lld:lifeskim |
| pubmed-article:7679745 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:7679745 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:7679745 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7679745 | pubmed:dateCreated | 1993-3-23 | lld:pubmed |
| pubmed-article:7679745 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7679745 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7679745 | pubmed:abstractText | The virulent Trinidad donkey (TRD) strain of Venezuelan equine encephalitis (VEE) virus and its live attenuated vaccine derivative, TC-83 virus, have different neurovirulence characteristics. A full-length cDNA clone of the TC-83 virus genome was constructed behind the bacteriophage T7 promoter in the polylinker of plasmid pUC18. To identify the genomic determinants of TC-83 virus attenuation, TRD virus-specific sequences were inserted into the TC-83 virus clone by in vitro mutagenesis or recombination. Antigenic analysis of recombinant viruses with VEE E2- and E1-specific monoclonal antibodies gave predicted antigenic reactivities. Mouse challenge experiments indicated that genetic markers responsible for the attenuated phenotype of TC-83 virus are composed of genome nucleotide position 3 in the 5'-noncoding region and the E2 envelope glycoprotein. TC-83 virus amino acid position E2-120 appeared to be the major structural determinant of attenuation. Insertion of the TRD virus-specific 5'-noncoding region, by itself, into the TC-83 virus full-length clone did not alter the attenuated phenotype of the virus. However, the TRD virus-specific 5'-noncoding region enhanced the virulence potential of downstream TRD virus amino acid sequences. | lld:pubmed |
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| pubmed-article:7679745 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7679745 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7679745 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7679745 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7679745 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7679745 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7679745 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:7679745 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:7679745 | pubmed:author | pubmed-author:URATAGG | lld:pubmed |
| pubmed-article:7679745 | pubmed:author | pubmed-author:TsuchiyaK RKR | lld:pubmed |
| pubmed-article:7679745 | pubmed:author | pubmed-author:RoehrigJ TJT | lld:pubmed |
| pubmed-article:7679745 | pubmed:author | pubmed-author:ChangG JGJ | lld:pubmed |
| pubmed-article:7679745 | pubmed:author | pubmed-author:KinneyR MRM | lld:pubmed |
| pubmed-article:7679745 | pubmed:author | pubmed-author:SneiderJ MJM | lld:pubmed |
| pubmed-article:7679745 | pubmed:author | pubmed-author:WoodwardT MTM | lld:pubmed |
| pubmed-article:7679745 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7679745 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:7679745 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7679745 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7679745 | pubmed:pagination | 1269-77 | lld:pubmed |
| pubmed-article:7679745 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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