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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1993-3-16
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L09230,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L20501,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L33702,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L33703,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L33704,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L33705,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L33706,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L33707,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L33708,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L33709,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M99293,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X17403
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pubmed:abstractText |
The immunoregulatory proteins C-C chemokines are potent chemoattractants of lymphocytes and monocytes, as well as activators and attractants of eosinophils and basophils. We have isolated a cDNA that encodes a seven transmembrane-spanning receptor, with homology to other chemoattractant receptors, that encodes a protein designated C-C CKR-1 that acts as a receptor for the C-C chemokines. Human and murine macrophage inflammatory protein 1 alpha (MIP-1 alpha), human human monocyte chemotactic protein 1 (MCP-1), and RANTES all bind to the C-C CKR-1 with varying affinities. Chemokine binding affinity does not predict how well the ligand will transmit a signal through the receptor: RANTES and human MIP-1 alpha induce a similar intracellular calcium flux while binding with disparate affinities, while MCP-1 and human MIP-1 beta induce calcium mobilization only at high concentrations. Finally, C-C chemokines were shown to bind a C-C CKR-1-related gene product encoded by cytomegalovirus, suggesting a role for C-C chemokines in viral immunity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL3,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL4,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL5,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Inflammatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Monokines,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Structural Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
72
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pubmed:geneSymbol |
C5AR,
CKR-1,
FMLPR,
IL8RA,
IL8RB,
STSR
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
415-25
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:7679328-Amino Acid Sequence,
pubmed-meshheading:7679328-Binding, Competitive,
pubmed-meshheading:7679328-Calcium,
pubmed-meshheading:7679328-Cells, Cultured,
pubmed-meshheading:7679328-Chemokine CCL3,
pubmed-meshheading:7679328-Chemokine CCL4,
pubmed-meshheading:7679328-Chemokine CCL5,
pubmed-meshheading:7679328-Cloning, Molecular,
pubmed-meshheading:7679328-Cytokines,
pubmed-meshheading:7679328-Cytomegalovirus,
pubmed-meshheading:7679328-DNA,
pubmed-meshheading:7679328-Genes, Viral,
pubmed-meshheading:7679328-Humans,
pubmed-meshheading:7679328-Lymphokines,
pubmed-meshheading:7679328-Macrophage Inflammatory Proteins,
pubmed-meshheading:7679328-Molecular Sequence Data,
pubmed-meshheading:7679328-Monokines,
pubmed-meshheading:7679328-Oligopeptides,
pubmed-meshheading:7679328-Open Reading Frames,
pubmed-meshheading:7679328-Receptors, Cell Surface,
pubmed-meshheading:7679328-Sequence Alignment,
pubmed-meshheading:7679328-Signal Transduction,
pubmed-meshheading:7679328-Viral Proteins,
pubmed-meshheading:7679328-Viral Structural Proteins
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pubmed:year |
1993
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pubmed:articleTitle |
Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor.
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pubmed:affiliation |
Department of Immunology, Genentech, Incorporated, South San Francisco, California 94080.
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pubmed:publicationType |
Journal Article,
In Vitro
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