| pubmed-article:7678597 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7678597 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:7678597 | lifeskim:mentions | umls-concept:C0206116 | lld:lifeskim |
| pubmed-article:7678597 | lifeskim:mentions | umls-concept:C0021755 | lld:lifeskim |
| pubmed-article:7678597 | lifeskim:mentions | umls-concept:C0164209 | lld:lifeskim |
| pubmed-article:7678597 | lifeskim:mentions | umls-concept:C0038585 | lld:lifeskim |
| pubmed-article:7678597 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:7678597 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:7678597 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:7678597 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:7678597 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:7678597 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7678597 | pubmed:dateCreated | 1993-2-19 | lld:pubmed |
| pubmed-article:7678597 | pubmed:abstractText | Substance P (SP) is a central and peripheral neurotransmitter which has been found in multiple sclerosis plaques. SP stimulates peripheral immune cells and may play a role in some chronic inflammatory diseases. Human peripheral monocyte/macrophages have been shown to produce the inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha) in response to SP. Therefore, in this study we examined rat brain microglia for the presence of SP receptors and production of IL-1 and TNF alpha in response to SP. Microglia had 4900 +/- 950 (mean +/- SE) receptors per cell fitting a two-site model. Four percent of these were high-affinity receptors with a Kd of 8.2 x 10(-8) M +/- 3.6 x 10(-8) M (mean +/- SE), and 96% of them were low-affinity receptors with a Kd of 2.1 x 10(-6) M +/- 5.2 x 10(-7) M (mean +/- SE). Competitive studies with CP 96,345 and other SP analogs demonstrate these to be non-classical NK-1 receptors. SP alone did not stimulate IL-1 or TNF alpha production. However, SP in synergy with lipopolysaccharide (LPS) quadrupled IL-1 production compared to LPS alone, but did not affect TNF alpha production. These results have implications for certain inflammatory conditions in the central nervous system. | lld:pubmed |
| pubmed-article:7678597 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7678597 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7678597 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7678597 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7678597 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7678597 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7678597 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7678597 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7678597 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7678597 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7678597 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7678597 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7678597 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7678597 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:7678597 | pubmed:issn | 0165-5728 | lld:pubmed |
| pubmed-article:7678597 | pubmed:author | pubmed-author:MerrillJ EJE | lld:pubmed |
| pubmed-article:7678597 | pubmed:author | pubmed-author:ShanahanFF | lld:pubmed |
| pubmed-article:7678597 | pubmed:author | pubmed-author:MartinF CFC | lld:pubmed |
| pubmed-article:7678597 | pubmed:author | pubmed-author:GornbeinJ AJA | lld:pubmed |
| pubmed-article:7678597 | pubmed:author | pubmed-author:AntonP APA | lld:pubmed |
| pubmed-article:7678597 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7678597 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:7678597 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7678597 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7678597 | pubmed:pagination | 53-60 | lld:pubmed |
| pubmed-article:7678597 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7678597 | pubmed:meshHeading | pubmed-meshheading:7678597-... | lld:pubmed |
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| pubmed-article:7678597 | pubmed:meshHeading | pubmed-meshheading:7678597-... | lld:pubmed |
| pubmed-article:7678597 | pubmed:meshHeading | pubmed-meshheading:7678597-... | lld:pubmed |
| pubmed-article:7678597 | pubmed:meshHeading | pubmed-meshheading:7678597-... | lld:pubmed |
| pubmed-article:7678597 | pubmed:meshHeading | pubmed-meshheading:7678597-... | lld:pubmed |
| pubmed-article:7678597 | pubmed:meshHeading | pubmed-meshheading:7678597-... | lld:pubmed |
| pubmed-article:7678597 | pubmed:meshHeading | pubmed-meshheading:7678597-... | lld:pubmed |
| pubmed-article:7678597 | pubmed:meshHeading | pubmed-meshheading:7678597-... | lld:pubmed |
| pubmed-article:7678597 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7678597 | pubmed:articleTitle | Production of interleukin-1 by microglia in response to substance P: role for a non-classical NK-1 receptor. | lld:pubmed |
| pubmed-article:7678597 | pubmed:affiliation | Department of Neurology, School of Medicine, University of California, Los Angeles 90024. | lld:pubmed |
| pubmed-article:7678597 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7678597 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7678597 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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