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rdf:type |
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lifeskim:mentions |
umls-concept:C0027651,
umls-concept:C0035015,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0439851,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1513095,
umls-concept:C1548437,
umls-concept:C1552596,
umls-concept:C1706438,
umls-concept:C1882923,
umls-concept:C1947931,
umls-concept:C2698600
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pubmed:issue |
5093
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|
pubmed:dateCreated |
1993-2-9
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|
pubmed:abstractText |
A variety of tumors are potentially immunogenic but do not stimulate an effective anti-tumor immune response in vivo. Tumors may be capable of delivering antigen-specific signals to T cells, but may not deliver the costimulatory signals necessary for full activation of T cells. Expression of the costimulatory ligand B7 on melanoma cells was found to induce the rejection of a murine melanoma in vivo. This rejection was mediated by CD8+ T cells; CD4+ T cells were not required. These results suggest that B7 expression renders tumor cells capable of effective antigen presentation, leading to their eradication in vivo.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0036-8075
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
259
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
368-70
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7678351-Animals,
pubmed-meshheading:7678351-Antigen-Presenting Cells,
pubmed-meshheading:7678351-Antigens, CD80,
pubmed-meshheading:7678351-Antigens, Surface,
pubmed-meshheading:7678351-CD4-Positive T-Lymphocytes,
pubmed-meshheading:7678351-Cross Reactions,
pubmed-meshheading:7678351-Female,
pubmed-meshheading:7678351-Gene Expression Regulation,
pubmed-meshheading:7678351-Genetic Vectors,
pubmed-meshheading:7678351-Ligands,
pubmed-meshheading:7678351-Lymphocyte Activation,
pubmed-meshheading:7678351-Melanoma,
pubmed-meshheading:7678351-Mice,
pubmed-meshheading:7678351-Mice, Inbred BALB C,
pubmed-meshheading:7678351-Mice, Inbred C3H,
pubmed-meshheading:7678351-Mice, Nude,
pubmed-meshheading:7678351-T-Lymphocytes, Regulatory,
pubmed-meshheading:7678351-Transfection,
pubmed-meshheading:7678351-Tumor Cells, Cultured
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pubmed:year |
1993
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pubmed:articleTitle |
Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells.
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pubmed:affiliation |
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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