Linked Life Data

7678215

Source:http://linkedlifedata.com/resource/pubmed/id/7678215

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-2-5
pubmed:abstractText
The effects of Peptide YY (PYY) on pancreatic and intestinal growth have been investigated in conscious rats. Male Wistar rats equipped with jugular vein cannulas were randomly assigned to five groups. All rats received continuous i.v. infusion of gut peptides for 4 days, rats were then killed, and the pancreas and intestine were analyzed. Infusion of PYY alone at the dose of 400 pmol/kg.h affected neither pancreatic weight, DNA and RNA contents, or the duodenal weight, protein, DNA and RNA contents. Infusion of caerulein at the dose of 0.25 microgram/kg.h significantly increased pancreatic weight, DNA, RNA, and protein contents by 202%, 109%, 171%, 183% above control values, but it did not affect duodenal weight, DNA, RNA, and protein contents. PYY, 400 pmol/kg.h, infused simultaneously with caerulein significantly reduced by 39%, 35%, and 45% increases in pancreatic weight, RNA and DNA contents stimulated by caerulein, respectively. Surprisingly, administration of PYY antiserum also resulted in a small but significant reduction in caerulein-stimulated pancreatic weight, protein, and DNA contents. In conclusion, PYY has an inhibitory effect on cholecystokinin-stimulated pancreatic growth and may play a physiological role as an inhibitor of pancreatic growth.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0013-7227
pubmed:author
pubmed:issnType
Print
pubmed:volume
132
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
219-23
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Effects of peptide YY on the growth of the pancreas and intestine.
pubmed:affiliation
Département de Biologie, Faculté des Sciences, Université de Sherbrooke, Québec, Canada.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't