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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
2
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pubmed:dateCreated |
1995-10-19
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pubmed:abstractText |
An analog of omega-conotoxin MVIIC (Y13A-MVIIC) was synthesized by replacing Tyr13 with Ala to study the role of Tyr13 residue conserved in many omega-conotoxins. Y13A-MVIIC has an overall conformation similar to that of the native toxin, but an enormously reduced ability to displace 125I-omega-conotoxin MVIIC binding to rat cerebellar P2 membranes. These results suggest that Tyr13 is essential for the activity of omega-conotoxins at P/Q-type calcium channels.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
214
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
305-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7677735-Amino Acid Sequence,
pubmed-meshheading:7677735-Animals,
pubmed-meshheading:7677735-Binding, Competitive,
pubmed-meshheading:7677735-Binding Sites,
pubmed-meshheading:7677735-Calcium Channel Blockers,
pubmed-meshheading:7677735-Calcium Channels,
pubmed-meshheading:7677735-Cell Membrane,
pubmed-meshheading:7677735-Cerebellum,
pubmed-meshheading:7677735-Conserved Sequence,
pubmed-meshheading:7677735-Disulfides,
pubmed-meshheading:7677735-Kinetics,
pubmed-meshheading:7677735-Molecular Sequence Data,
pubmed-meshheading:7677735-Peptides,
pubmed-meshheading:7677735-Protein Conformation,
pubmed-meshheading:7677735-Purkinje Cells,
pubmed-meshheading:7677735-Rats,
pubmed-meshheading:7677735-Sequence Homology, Amino Acid,
pubmed-meshheading:7677735-Tyrosine,
pubmed-meshheading:7677735-omega-Conotoxins
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pubmed:year |
1995
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pubmed:articleTitle |
Tyr13 is essential for the binding of omega-conotoxin MVIIC to the P/Q-type calcium channel.
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pubmed:affiliation |
Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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