rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
1995-10-19
|
pubmed:abstractText |
Mounting clinical and experimental evidence suggests that postoperative myocardial dysfunction is a frequent consequence of surgical global ischemia and reperfusion, despite our modern techniques of myocardial protection. The ubiquitous use of hyperkalemic depolarizing solutions in all forms of cardioplegia may be partly responsible for this phenomenon because of the known ongoing metabolic processes and damaging transmembrane ionic fluxes that occur at depolarized membrane potentials. Cardiac arrest at hyperpolarized potentials, the natural resting state of the heart, may avoid the shortcomings of depolarized arrest and provide an alternative means of myocardial protection.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0003-4975
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
60
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
858-63
|
pubmed:dateRevised |
2010-3-24
|
pubmed:meshHeading |
pubmed-meshheading:7677547-Animals,
pubmed-meshheading:7677547-Cardioplegic Solutions,
pubmed-meshheading:7677547-Cardiopulmonary Bypass,
pubmed-meshheading:7677547-Disease Models, Animal,
pubmed-meshheading:7677547-Heart Arrest, Induced,
pubmed-meshheading:7677547-Membrane Potentials,
pubmed-meshheading:7677547-Myocardial Reperfusion,
pubmed-meshheading:7677547-Picolines,
pubmed-meshheading:7677547-Potassium,
pubmed-meshheading:7677547-Potassium Channels,
pubmed-meshheading:7677547-Pyrans,
pubmed-meshheading:7677547-Swine
|
pubmed:year |
1995
|
pubmed:articleTitle |
Is there an alternative to potassium arrest?
|
pubmed:affiliation |
Department of Surgery, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0645, USA.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Review
|