Linked Life Data

7676485

Source:http://linkedlifedata.com/resource/pubmed/id/7676485

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1995-10-19
pubmed:abstractText
It has been hypothesized that immunoregulating cytokines produced by intragraft Th-2 cells may be important for prolonged allograft survival. ACI hearts transplanted into untreated Lewis rat recipients survived for 6.2 days, but they survived for 72.1 days in recipients treated with a donor-specific transfusion and low dose CsA for 14 days. In donor-specific transfusion/CsA-treated animals, intragraft infusion of IL-10 via a 14-day osmotic minipump had no effect on graft survival (75.6 days), but intragraft infusion of IL-4 prolonged graft survival to 149.2 days (P < 0.01). While the actual mechanism of this effect is unclear, it suggests that IL-4 may be important in the development of long-term graft survival.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0041-1337
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
405-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Administration of intragraft interleukin-4 prolongs cardiac allograft survival in rats treated with donor-specific transfusion/cyclosporine.
pubmed:affiliation
Department of Surgery, University of Cincinnati Medical Center, Ohio 45267-0558, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't