Linked Life Data

7675740

Source:http://linkedlifedata.com/resource/pubmed/id/7675740

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-10-17
pubmed:abstractText
With use of the International Normalized Ratio (INR), physicians can accurately assess the intensity of anticoagulation in treatment programs and trials. Bleeding is the major complication of oral anticoagulant therapy, and its incidence can be lessened, with no loss of efficacy, by using less intense therapy (INR, 2 to 3). INRs above the target range, marked variability in INRs, newly initiated therapy, previous bleeding, and a serious comorbid condition all constitute significant risk factors. While age over 65 is not a proven risk factor, the elderly are more sensitive to the effects of warfarin and require smaller doses. Meticulous attention should be paid to the concomitant use of any medications that may affect metabolism of warfarin or induce a concomitant qualitative platelet effect (specifically, aspirin and nonsteroidal antiinflammatory drugs) and to dietary modifications that significantly change vitamin K intake. Hematuria or gastrointestinal bleeding should always be assessed, since the chance of finding a clinically significant lesion is good, especially when the INR has been in the therapeutic range. While a minor prolongation of the INR without bleeding may be treated by watchful waiting, vitamin K administration and other therapeutic measures may be necessary in patients who are actively bleeding.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0032-5481
pubmed:author
pubmed:issnType
Print
pubmed:volume
98
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
153-4, 159-62, 164-5, passim
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
When bleeding complicates oral anticoagulant therapy. How to anticipate, investigate, and treat.
pubmed:affiliation
Metro-McNair Clinical Laboratories, Victoria, British Columbia.
pubmed:publicationType
Journal Article, Review, Case Reports