Linked Life Data

7673713

Source:http://linkedlifedata.com/resource/pubmed/id/7673713

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1995-10-16
pubmed:abstractText
The development of influenza virus-specific CD8+ cytotoxic T lymphocyte precursors (CTLp) is diminished in H-2b mice that are homozygous (-/-) for disruption of the H-2lAb gene. Virus clearance was not obviously delayed when compared with the congenic H-2lAb (+/+) controls, and evidence of CTL activity was apparent for inflammatory cells recovered from the respiratory tract in both cases. However, the virus-specific CTLp that are normally present in the regional lymph nodes and in the infected lung were evidently being consumed at the peak of the host response to give the terminally differentiated CTL effectors. Even so, any exhaustion of the CTLp pool was apparently transitory with this localized infection as, though the frequencies were consistently lower than those found for the (+/+) controls, CTLp could be detected reproducibly in both lymph nodes and spleen through 14 mo after infection. Analysis of cytokine profiles during the acute response showed a substantial defect in the (-/-) mice, indicating that cytokine production is largely dependent on the influenza-specific CD4+ set.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
155
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2955-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Characteristics of the influenza virus-specific CD8+ T cell response in mice homozygous for disruption of the H-2lAb gene.
pubmed:affiliation
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't