Linked Life Data

7672039

Source:http://linkedlifedata.com/resource/pubmed/id/7672039

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-10-18
pubmed:abstractText
Experimental thiamine deficiency (TD) is a classical model of metabolic encephalopathy and selective cell loss in the brain resulting from a generalized, low-grade oxidative deficit. Late stages of TD are characterized by hemorrhages in the brain indicating a disruption of the blood-brain barrier (BBB). However, the relation of the breakdown of the BBB to selective cell loss in TD is not understood. The current studies examined the BBB at different stages of TD using immunoglobulin G (IgG) as an indicator of BBB integrity. Adult rats received thiamine-deficient diet ad libitum and daily injections of the thiamine antagonist pyrithiamine. IgG immunoreactivity increased in the inferior colliculus and inferior olive as early as 10 days after the initiation of TD and prior to the onset of cell death and hemorrhage. After 11 or 12 days, IgG immunoreactivity increased in multiple vulnerable regions. On Day 13, intense IgG immunoreactivity was found in regions of tissue damage and hemorrhage such as the thalamus, inferior colliculus, mammillary body, medial geniculate nucleus, medial vestibular nucleus, and inferior olive. Nonvulnerable regions displayed little or no IgG immunoreactivity. Immunoblotting analysis confirmed the presence of IgG in vulnerable areas such as the thalamus and inferior colliculus but not in preserved regions such as the cortex. Preliminary electron microscopy of capillary endothelia in areas of IgG accumulation in the thalamus at Day 13 revealed perivascular edema and intact interendothelial tight junctions.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0014-4886
pubmed:author
pubmed:issnType
Print
pubmed:volume
134
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
64-72
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Blood-brain barrier abnormalities in vulnerable brain regions during thiamine deficiency.
pubmed:affiliation
Cornell University Medical College, Burke Medical Research Institute, White Plains, New York 10605, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.