Linked Life Data

7670879

Source:http://linkedlifedata.com/resource/pubmed/id/7670879

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1995-10-18
pubmed:abstractText
Central cardiovascular effects of cholinergic agonists depend on the dose, site and mode of administration, species, and to the state of the animal. Intravenous injection of physostigmine and intracerebroventricular injection of carbachol produced pressor and tachycardic responses in urethane-anesthetized rats. Both agents also elicited pressor responses in conscious rats, but bradycardia occurred in the presence of anesthesia. Additionally, pressor responses to physostigmine, but not to carbachol, were significantly exaggerated by urethane anesthesia. These results demonstrate that anesthesia depresses cardiovascular reflexes and the inhibitory control mechanisms on acetylcholine release from the nerve endings involved in cardiovascular regulation. The role of the central nucleus of the amygdala (CNA) was also investigated in this study. The pressor effects of intracerebroventricular injection of carbachol were significantly attenuated by electrolytic ablation of the CNA, but heart rate changes were not altered both in anesthetized and conscious rats. These results indicate that the CNA plays a role in cholinergic control of blood pressure, but not in the regulation of heart rate.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0361-9230
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
569-73
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Cardiovascular effects of centrally active cholinomimetics in conscious and anesthetized rats: the role of amygdala.
pubmed:affiliation
Department of Physiology, Marmara University School of Medicine, Istanbul, Turkey.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't