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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1995-10-18
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pubmed:abstractText |
The chloride channel gene, CLCN4, has been previously mapped to the X chromosome in humans. We isolated a cDNA clone for mouse Clcn4 and used this to map the gene in an interspecific backcross. This revealed the surprising finding that the gene maps to the X chromosome in Mus spretus but to chromosome 7 in C57BL/6 mice. This is the first example of a gene that contravenes Ohno's law--it is a gene unique to the X chromosome in one eutherian species but autosomal in another. The consequence of this chromosomal rearrangement is that the gene is lost by mendelian segregation in a subset of the male progeny of a (C57BL/6 x Mus spretus) x Mus spretus backcross.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1061-4036
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
472-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7670497-Amino Acid Sequence,
pubmed-meshheading:7670497-Animals,
pubmed-meshheading:7670497-Base Sequence,
pubmed-meshheading:7670497-Chloride Channels,
pubmed-meshheading:7670497-Chromosome Mapping,
pubmed-meshheading:7670497-Cloning, Molecular,
pubmed-meshheading:7670497-Crosses, Genetic,
pubmed-meshheading:7670497-DNA,
pubmed-meshheading:7670497-Dosage Compensation, Genetic,
pubmed-meshheading:7670497-Female,
pubmed-meshheading:7670497-Humans,
pubmed-meshheading:7670497-Male,
pubmed-meshheading:7670497-Mice,
pubmed-meshheading:7670497-Mice, Inbred C57BL,
pubmed-meshheading:7670497-Models, Genetic,
pubmed-meshheading:7670497-Molecular Sequence Data,
pubmed-meshheading:7670497-Muridae,
pubmed-meshheading:7670497-Rats,
pubmed-meshheading:7670497-X Chromosome
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pubmed:year |
1995
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pubmed:articleTitle |
A contravention of Ohno's law in mice.
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pubmed:affiliation |
CRC Centre for Cell and Molecular Biology, Chester Beatty Laboratories, Institute of Cancer Research, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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