Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1995-10-18
|
| pubmed:abstractText |
We report a case of indolent B-chronic lymphocytic leukaemia (B-CLL) in a stage A patient, treated for 10 years only by theophylline for bronchial asthma. As suggested by the spontaneous apoptosis in the patient's blood (10%), theophylline at 50 micrograms/ml increased spontaneous apoptosis after 72 h in culture by a mean percentage of 90% (range 79-98%) in six B-CLL cases studied in vitro. This effect was partially reversed with Rp-cAMP, a cAMP antagonist, which implies a potent role for this second messenger. We describe a new property of theophylline, which might be an alternative treatment in B-CLL.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0007-1048
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
90
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
957-9
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7669680-Aged,
pubmed-meshheading:7669680-Apoptosis,
pubmed-meshheading:7669680-B-Lymphocytes,
pubmed-meshheading:7669680-Cyclic AMP,
pubmed-meshheading:7669680-Dose-Response Relationship, Drug,
pubmed-meshheading:7669680-Female,
pubmed-meshheading:7669680-Humans,
pubmed-meshheading:7669680-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:7669680-Lymphopenia,
pubmed-meshheading:7669680-Theophylline,
pubmed-meshheading:7669680-Thionucleotides
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Theophylline, a new inducer of apoptosis in B-CLL: role of cyclic nucleotides.
|
| pubmed:affiliation |
Département d'Hématologie, Unité Claude Bernard C20, Hôpital Pitié-Salpêtrière, Paris, France.
|
| pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|